Isoptin SR

Verapamil HCl

Essential HTN, CAD, paroxysmal supraventricular tachycardia, atrial fibrillation (AF).

Adult 120-480 mg in 1-2 divided doses.

Should be taken with food: Swallow whole, do not chew/crush.

CV shock, 2nd-3rd AV block, sick sinus syndrome, heart failure w/ left ventricular ejection fraction <35%, AF w/ accessory bypass tract. Concomitant use w/ ivabradine.

Complicated acute MI, heart block/1st degree AV block/bradycardia/asystole, neuromuscular transmission disorders. Severe hepatic/renal impairment.

Dizziness, headache, bradycardia, flushing, hypotension, constipation, nausea, peripheral edema.

Concomitant use w/ α-blockers (prazosin, terazosin), antiarrhythmics (flecainide, quinidine), antiasthmatics (theophylline), anticonvulsants/anti-epileptics (carbamazepine, phenytoin), antidepressants (imipramine), antidiabetics (glyburide, metformin), anti-gout (colchicine), anti-infectives (clarithromycin, erythromycin, rifampicin, telithromycin), antineoplastics (doxorubicin), barbiturates (phenobarb), benzodiazepines & other anxiolytics (buspirone, midazolam), β-blockers (metoprolol, propranolol), cardiac glycosides (digitoxin, digoxin), H₂ receptor antagonists (cimetidine), immunologics/immunosuppressives (cyclosporine, everolimus, sirolimus, tacrolimus), lipid lowering agents (atorvastatin, lovastatin, simvastatin), serotonin receptor agonists (almotriptan), uricosurics (sulfinpyrazone), anticoagulants (dabigatran), direct oral anticoagulants, ivabradine, grapefruit juice, St. John's Wort.

Calcium Antagonists

C08DA01 - verapamil ; Belongs to the class of phenylalkylamine derivative selective calcium-channel blockers with direct cardiac effects. Used in the treatment of cardiovascular diseases.

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